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General Statement |
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| Our research is based on a confrontation between phenomenological and psychopathological studies of disorders involving the BG, using anatomical, behavioural, and physiological data. Precise anatomical locations of both electrophysiological and imaging data, using an original histological 3D atlas, allow us to model the different circuits involved and their interactions. New therapeutic hypotheses are tested in parallel through clinical trials and animal experiments. |
| This research program is carried out in healthy human volunteers and in patients with Parkinson's Disease, Tourette Syndrome, Obsessive-Compulsive Disorder, Depression, Cocaine Dependence, included in experimental clinical protocols that are promoted by institutional authorities (AP-HP, Inserm, CNRS) and agreed upon by local ethic committees. |
| Techniques used |
- Experimental psychology and functional neuroimaging;
- Three-dimensional (3D) atlas and high field anatomical MRI; diffusion-tensor imaging (DTI);
- Voxel-based morphometry (VBM);
- Development of imaging and stereotactic tools for DBS;
- Transcranial magnetic stimulation (TMS);
- Intracranial electrophysiological recordings of single-unit neuronal activity and local field potentials;
- Multiscale integration of functional data and atlas-based anatomy in the human basal ganglia;
- Animal models and experimental therapeutics (rodents, primates).
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| Therapeutic innovations |
- Evaluation of new Cognitive Behavioural Therapy (CBT) techniques using experimental paradigms;
- Repetitive transcranial magnetic stimulation (rTMS)
- Development of innovative neurosurgical treatments using DBS in neuropsychiatric disorders.
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Hôpital de la Pitié-Salpêtrière Bâtiment Paul Castaigne - Centre d’Investigation Clinique
47 boulevard de l’Hôpital, F-75013, Paris |
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